Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner
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منابع مشابه
KLF 4 ( Kruppel - like factor 4 ( gut ) )
A full-length mouse cDNA clone encoding KLF4 was initially isolated from a NIH3T3 cDNA library by reduced stringency screening with a DNA probe containing the zinc finger region of an immediate early gene product, Zif268 or Egr1. A distinct feature of the KLF4 gene is the highly GC-rich nature of the sequence near its 5'-end. Thus, the G+C content of the 1000 nt 5'-flanking region is 67% and th...
متن کاملKruppel like factor 4 ( KLF 4 ) : a transcription factor with diverse context - dependent functions Review
Hima Vangapandu1, Walden Ai1* Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Building 2, Room B18, Columbia, SC 29209, USA __________________________________________________________________________________________________ *Correspondence: Dr. Walden Ai, Assistant Professor, Department of Pathology, Microbiology and...
متن کاملThe tumor suppressor Kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner.
The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand activation leads to AhR nuclear translocat...
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Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. KLF4 is also a tumor suppressor in certain cancers. KLF4 can be an indicator of stem-like capacity in embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs), etc. The KLF4 gene is conserved in chimpanzee, Rhesus monkey...
متن کاملRegulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
Type I cGMP-dependent protein kinase (PKG I) plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, but little is known about the regulation of PKG I expression in smooth muscle cells. We found opposing effects of RhoA and Rac1 on cellular PKG I expression: (i) cell density-dependent changes in PKG I expression varied directly with Rac1 act...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2021
ISSN: 1535-9476
DOI: 10.1016/j.mcpro.2021.100064